Yes! The downloadable Inklingo collections work on Mac. That is one of the reasons for making the change from CDs.
The CDs for Inklingo # 1, # 2 and # 3 only work on the PC side of a Mac.
My ability to provide support for Mac users is limited because I don't have a Mac myself. So far, this has not been a problem, either because Inklingo is easy to use (yes!), or because Mac users are especially smart, or because they have been helped by one of the several friendly quilters in the Yahoo Group who use Inklingo on Mac.